Blimp-1–dependent and –independent natural antibody production by B-1 and B-1–derived plasma cells
نویسندگان
چکیده
منابع مشابه
Blimp-1–dependent and –independent natural antibody production by B-1 and B-1–derived plasma cells
Natural antibodies contribute to tissue homeostasis and protect against infections. They are secreted constitutively without external antigenic stimulation. The differentiation state and regulatory pathways that enable continuous natural antibody production by B-1 cells, the main cellular source in mice, remain incompletely understood. Here we demonstrate that natural IgM-secreting B-1 cells in...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2017
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20161122